Asparagine-Selective Cleavage of Peptide Bonds through Hypervalent Iodine-Mediated Hofmann Rearrangement in Neutral Aqueous Solution

Chem. Sci., 2014, Accepted ManuscriptDOI: 10.1039/C3SC53037J, Edge Article Kana Tanabe, Atsuhiko Taniguchi, Takuya Matsumoto, Kounosuke Oisaki, Youhei Sohma, Motomu KanaiAmide bonds of peptides and proteins are generally unreactive toward hydrolysis, but backbone amide bond cleavage at a specific amino acid-site … Continue reading →



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